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Palytoxin and similar toxins are highly potent Na⁺-K⁺ ATPase inhibitors occurring in zoanthid corals (Palythoa toxica), red alga, a sea anemone and in dinoflagellates such as Ostrepsis siamensis. It affects humans lethally when ingested in reef fish, crabs and shellfish (sometimes associated with ciguatoxins, saxitoxins and tetrodotoxin), and non-lethally after dermal and ocular exposure, especially in aquarium keepers. Clinical effects include acute gastrointestinal symptoms followed by paraesthesiae, hypertension, distorted sense of taste (dysguesia), rhabdomyolysis, cardiac dysrhythmias, respiratory failure, and coma, rapidly progressing to death. There is no specific treatment